For East Coast fishing with easy access, good accomodations and great fishing you should look at the area from Playalinda on the north to Jupiter on the south.
This will put you within easy driving distance of Sebastian Inlet, Ft. Pierce Inlet & beaches, Jensen Beach, St. Lucie Inlet, Juno beaches and piers and some of Florida's consistently best beach and river fishing.
It also give you the opportunity to fish the flats and bridges of the Indian River up and down the coast for trout, reds, tarpon and snook.