From what I've been told, each should be individually blocked since each URL is unique. Personally, I'm not sure if there is a better way or not. Are you still seeing a lot of these popping up (pardon the pun) or are the starting to subside a bit?
Sorry about the delay getting back to you on this. You should no longer see the overlay ad for Amazon Prime day. It was part of an ad campaign for prime day. Sorry for any inconveniences the ad caused.